Ocimum basilicum L. (Lamiaceae) leaves aqueous extract improve learning and memory in the monosodium glutamate-induced neurotoxicity model of Alzheimer's disease through attenuating brain oxidative damage in experimental mice

Ethnopharmacological relevance: Ocimum basilicum L. (Lamiaceae) is a medicinal plant known in Cameroon for the treatment of many ailments like anxiolytic, antispasmodic and mental disorders. Aim study: The aim this study to evaluate neuroprotective effects basilicum. Materials methods: T-maze test open field assay oxidative stress parameters were used detecting its capacity protect neurons against excitotoxicity induced by monosodium glutamate. Results: It was found that significantly increased time spent preferred arm as well number entries same arm. first choice latency decreased animals treated compared those with glutamate monosodium. In test, it noted an increase center lines crossed. Results shows reversed damage Glutamate reducing levels MDA increasing concentration CAT, GSH, SOD negative distilled water groups respectively [F (5, 15) = 13.51; P < 0.001]; 12.42; (6, 24) 79.74; 0.001] 18.27; 0.001]. Conclusion: These results suggest possess neuroprotectives properties mice might involve action on antioxidant defense system central nervous